发育研究Cre工具鼠

在发育研究中，Cre-loxP系统同样是一个强大的工具，用于研究不同基因在发育过程中的功能和机制。以下是一些在发育研究中重要的Cre小鼠品系（依名称字母排序）及其参考文献：

1. Foxg1-Cre

Hébert, J. M., & McConnell, S. K. (2000). Targeting of cre to the Foxg1 (BF-1) locus mediates loxP recombination in the telencephalon and other developing head structures. Developmental Biology, 222(2), 296-306.

2. Hoxb1-Cre

Zhang, Z., Huynh, T., & Baldini, A. (2006). Mesodermal expression of Hoxb1 is required for posterior body wall development. Development, 133(12), 2325-2335.

3. Isl1-Cre

Yang, L., Cai, C. L., Lin, L., Qyang, Y., Chung, C., Monteiro, R. M., ... & Evans, S. (2006). Isl1Cre reveals a common Bmp pathway in heart and limb development. Development, 133(8), 1575-1585.

4. Mesp1-Cre

Saga, Y., Kitajima, S., & Miyagawa-Tomita, S. (2000). Mesp1 expression is the earliest sign of cardiovascular development. Trends in Cardiovascular Medicine, 10(9), 345-352.

5. Nkx2.5-Cre

Moses, K. A., DeMayo, F., Braun, R. M., Reecy, J. L., & Schwartz, R. J. (2001). Embryonic expression of an Nkx2-5/Cre gene using ROSA26 reporter mice. Genesis, 31(4), 176-180.

6. Pax3-Cre

Engleka, K. A., Gitler, A. D., Zhang, M., Zhou, D. D., High, F. A., & Epstein, J. A. (2005). Insertion of Cre into the Pax3 locus creates a new allele of Splotch and identifies unexpected Pax3 derivatives. Developmental Biology, 280(2), 396-406.

7. Shh-Cre

Harfe, B. D., Scherz, P. J., Nissim, S., Tian, H., McMahon, A. P., & Tabin, C. J. (2004). Evidence for an expansion-based temporal Shh gradient in specifying vertebrate digit identities. Cell, 118(4), 517-528.

8. Sox2-Cre

Hayashi, S., & McMahon, A. P. (2002). Efficient recombination in diverse tissues by a tamoxifen-inducible form of Cre: a tool for temporally regulated gene activation/inactivation in the mouse. Developmental Biology, 244(2), 305-318.

9. Tbx1-Cre

Xu, H., Beasley, D., & DePamphilis, M. L. (2002). Pervasive roles of a conserved DNA replication initiator protein in cell growth and development. Current Biology, 12(17), 1471-1477.

10. Wnt1-Cre

Danielian, P. S., Muccino, D., Rowitch, D. H., Michael, S. K., & McMahon, A. P. (1998). Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase. Current Biology, 8(24), 1323-1326.

结语